Dhiren R. Thakker: search on Z-Library

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1

[Biotechnology: Pharmaceutical Aspects] Optimizing the “Drug-Like” Properties of Leads in Drug Discovery Volume IV || Solubility, Solubilization and Dissolution in Drug Delivery During Lead Optimization

Borchardt, Ronald T., Kerns, Edward H., Hageman, Michael J., Thakker, Dhiren R., Stevens, James L.

Year:

2006

Language:

english

File:

PDF, 1.27 MB

english, 2006

2

Photoaffinity Labeling of the Anionic Sites in Caco-2 Cells Mediating Saturable Transport of Hydrophilic Cations Ranitidine and Famotidine

Bourdet, David L., Lee, Kiho, Thakker, Dhiren R.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 57 KB

english, 2004

3

Use of CACO-2 Cells as an in vitro Intestinal Absorption and Metabolism Model

Gan, Liang-Shang, Eads, Cindy, Niederer, Tara, Bridgers, Avis, Yanni, Souzan, Hsyu, Poe-Hirr, Pritchard, Fred J., Thakker, Dhiren

Journal:

Drug Development and Industrial Pharmacy

Year:

1994

Language:

english

File:

PDF, 835 KB

english, 1994

4

Cellular Delivery of Nucleoside Diphosphates: A Prodrug Approach

Shin Hong Kang, Achintya K. Sinhababu, Joseph G. Cory, Beverly S. Mitchell, Dhiren R. Thakker, Moo J. Cho

Journal:

Pharmaceutical Research

Year:

1997

File:

PDF, 676 KB

1997

5

Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers

Kiho Lee, Dhiren R. Thakker

Journal:

Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 113 KB

english, 1999

6

Exploring the role of the pharmacist in global health

Steeb, David R., Joyner, Pamela U., Thakker, Dhiren R.

Journal:

Journal of the American Pharmacists Association

Year:

2014

Language:

english

File:

PDF, 468 KB

english, 2014

7

High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism

John H. Ansede, Dhiren R. Thakker

Journal:

Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 245 KB

english, 2004

8

Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding

Souzan B. Yanni, P. Brian Smith, Daniel K. Benjamin Jr, Patrick F. Augustijns, Dhiren R. Thakker, Pieter P. Annaert

Journal:

Biopharmaceutics & Drug Disposition

Year:

2011

Language:

english

File:

PDF, 261 KB

english, 2011

9

Catechol O-methyltransferase. 8. Structure-activity relationships for inhibition by 8-hydroxyquinolines

Borchardt, Ronald T., Thakker, Dhiren R., Warner, Victor D., Mirth, Dale B., Sane, Jayant N.

Journal:

Journal of Medicinal Chemistry

Year:

1976

Language:

english

File:

PDF, 408 KB

english, 1976

10

Benzo-ring diol epoxides of benzo[e]pyrene and triphenylene

Yagi, Haruhiko, Thakker, Dhiren R., Lehr, Roland E., Jerina, Donald M.

Journal:

Journal of Organic Chemistry

Year:

1979

Language:

english

File:

PDF, 591 KB

english, 1979

11

[Biotechnology: Pharmaceutical Aspects] Optimizing the “Drug-Like” Properties of Leads in Drug Discovery Volume IV || The Relevance of Transporters in Determining Drug Disposition

Borchardt, Ronald T., Kerns, Edward H., Hageman, Michael J., Thakker, Dhiren R., Stevens, James L.

Year:

2006

Language:

english

File:

PDF, 289 KB

english, 2006

12

Synthesis, hydrolytic behavior, and anti-hiv activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium)

Radhakrishnan P. Iyer, Jila H. Boal, Lawrence R. Phillips, Dhiren R. Thakker, William Egan

Journal:

Journal of Pharmaceutical Sciences

Year:

1994

Language:

english

File:

PDF, 567 KB

english, 1994

13

Catechol O-methyltransferase. 6. Affinity labeling with N-haloacetyl-3,5-dimethoxy-4-hydroxyphenylalkylamines

Borchardt, Ronald T., Thakker, Dhiren R.

Journal:

Journal of Medicinal Chemistry

Year:

1975

Language:

english

File:

PDF, 840 KB

english, 1975

14

[Biotechnology: Pharmaceutical Aspects] Optimizing the “Drug-Like” Properties of Leads in Drug Discovery Volume IV ||

Borchardt, Ronald T., Kerns, Edward H., Hageman, Michael J., Thakker, Dhiren R., Stevens, James L.

Year:

2006

Language:

english

File:

PDF, 12.48 MB

english, 2006

15

Response to: “Prediction of Voriconazole Non-Linear Pharmacokinetics Using a Paediatric Physiologically Based Pharmacokinetic Modelling Approach”

Zane, Nicole R., Thakker, Dhiren R.

Journal:

Clinical Pharmacokinetics

Year:

2015

Language:

english

File:

PDF, 131 KB

english, 2015

16

Deconvoluting the effects of P-glycoprotein on intestinal CYP3A: a major challenge

Beverly Knight, Matthew Troutman, Dhiren R Thakker

Journal:

Current Opinion in Pharmacology

Year:

2006

Language:

english

File:

PDF, 223 KB

english, 2006

17

Synthesis of triphenylene 1,2-oxide (1,2-epoxy-1,2-dihydrophenylene) and absolute configuration of the trans-1,2-dihydro diol metabolite of triphenylene. Crystal structure of (?)-(1R,2R)-trans-2-bromo-1-menthylxyacetoxy-1,2,3,4-tetrahydrotriphenylene

Boyd, Derek R., Kennedy, Deirdre A., Malone, John F., O'Kane, Gerard A., Thakker, Dhiren T., Yagi, Heruhiko, Jerina, Donald M.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1987

Language:

english

File:

PDF, 906 KB

english, 1987

18

Cytochrome P450 and flavin-containing monooxygenase families: Age-dependent differences in expression and functional activity

Zane, Nicole R, Chen, Yao, Wang, Michael Zhuo, Thakker, Dhiren R

Journal:

Pediatric Research

Year:

2017

Language:

english

File:

PDF, 6.29 MB

english, 2017

19

Editorial announcement

Binghe Wang, Dhiren R. Thakker

Journal:

Medicinal Research Reviews

Year:

2001

Language:

english

File:

PDF, 36 KB

english, 2001

20

Prodrugs of anticancer agents

Achintya K. Sinhababu, Dhiren R. Thakker

Journal:

Advanced Drug Delivery Reviews

Year:

1996

Language:

english

File:

PDF, 3.10 MB

english, 1996

21

Synthesis of the K-region monofluoro- and difluorobenzo[c]phenanthrenes

Mirsadeghi, Seid, Prasad, Ganesh K. B., Whittaker, Noel, Thakker, Dhiren R.

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 880 KB

english, 1989

22

Efficacious Dose of Metformin for Breast Cancer Therapy is Determined by Cation Transporter Expression in Tumors

Cai, Hao, Everett, Ruth, Thakker, Dhiren R.

Journal:

British Journal of Pharmacology

Year:

2019

Language:

english

File:

PDF, 1.49 MB

english, 2019

23

Affinity labeling of catechol-O-methyltransferase with N-iodoacetyl-3,5-dimethoxy-4-hydroxy-phenylethylamine

Ronald T. Borchardt, Dhiren Thakker

Journal:

Biochemical and Biophysical Research Communications

Year:

1973

Language:

english

File:

PDF, 315 KB

english, 1973

24

The effect of steric strain in the bay-region of polycyclic aromatic hydrocarbons: Tumorigenicity of alkyl-substituted benz[a]anthracenes

Levin, Wayne, Wood, Alexander W., Chang, Richard L., Newman, Melvin S., Thakker, Dhiren R., Conney, Allan H., Jerina, Donald M.

Journal:

Year:

1983

Language:

english

File:

PDF, 632 KB

english, 1983

25

Metabolism of Benzo[a]pyrene: Conversion of (± )-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to Highly Mutagenic 7,8-diol-9,10-epoxides

Dhiren R. Thakker, Haruhiko Yagi, Anthony Y. H. Lu, Wayne Levin, Allan H. Conney and Donald M. Jerina

Journal:

Proceedings of the National Academy of Sciences

Year:

1976

Language:

english

File:

PDF, 1.23 MB

english, 1976

26

Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers

Dong-Zhou Liu, Edward L. Lecluyse, Dhiren R. Thakker

Journal:

Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 209 KB

english, 1999

27

[Biotechnology: Pharmaceutical Aspects] Optimizing the “Drug-Like” Properties of Leads in Drug Discovery Volume IV || Metabolic Activation-Role in Toxicity and Idiosyncratic Reactions

Borchardt, Ronald T., Kerns, Edward H., Hageman, Michael J., Thakker, Dhiren R., Stevens, James L.

Year:

2006

Language:

english

File:

PDF, 289 KB

english, 2006

28

Determination of the Androgen Receptor Inhibitor Enzalutamide and its Metabolites in Animal Plasma and Brain Homogenates Using LC-MS/MS and its Application to Pharmacokinetic Studies

OHTSU, Yoshiaki, R. THAKKER, Dhiren, A. GIBBONS, Jacqueline, TSUBOTA, Kenjiro, OTSUKA, Shohei, ARAI, Hiroshi

Journal:

Year:

2015

Language:

english

File:

PDF, 1.31 MB

english, 2015

29

Intestinal Absorptive Transport of the Hydrophilic Cation Ranitidine: A Kinetic Modeling Approach to Elucidate the Role of Uptake and Efflux Transporters and Paracellularvs.Transcellular Transport in Caco-2 Cells

David L. Bourdet, Gary M. Pollack, Dhiren R. Thakker

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 600 KB

english, 2006

30

Structure—activity relationships for enhancement of paracellular permeability by 2-alkoxy-3-alkylamidopropylphosphocholines across Caco-2 cell monolayers

Dong-Zhou Liu, Susan L. Morris-Natschke, Louis S. Kucera, Khalid S. Ishaq, Dhiren R. Thakker

Journal:

Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 102 KB

english, 1999

31

Vectorial Transport of Fexofenadine across Caco-2 Cells: Involvement of Apical Uptake and Basolateral Efflux Transporters

Ming, Xin, Knight, Beverly M., Thakker, Dhiren R

Journal:

Molecular Pharmaceutics

Year:

2011

Language:

english

File:

PDF, 2.01 MB

english, 2011

32

Characterizing the fragmentation of 2,5-bis (4-amidinophenyl)furan-bis-O-methylamidoxime and selected metabolites using ion trap mass spectrometry

Lian Zhou, Robert D. Voyksner, Dhiren R. Thakker, Chad E. Stephens, Mariappan Anbazhagan, David W. Boykin, James E. Hall, Richard R. Tidwell

Journal:

Rapid Communications in Mass Spectrometry

Year:

2002

Language:

english

File:

PDF, 193 KB

english, 2002

33

Mechanism of Intestinal Absorption of Ranitidine and Ondansetron: Transport Across Caco-2 Cell Monolayers

Liang-Shang Gan, Poe-Hirr Hsyu, J. Frederick Pritchard, Dhiren Thakker

Journal:

Pharmaceutical Research

Year:

1993

File:

PDF, 824 KB

1993

34

[Methods in Enzymology] Biomembranes - Part C: Biological Oxidations Volume 52 || [28] Analysis of polycyclic aromatic hydrocarbons and their metabolites by high-pressure liquid chromatography

Thakker, Dhiren R.

Year:

1978

Language:

english

File:

PDF, 903 KB

english, 1978

35

Modulation of the Tight Junctions of the Caco-2 Cell Monolayers by H2-antagonists

Liang-Shang L. Gan, Souzan Yanni, Dhiren R. Thakker

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 441 KB

1998

36

A Physiologically Based Pharmacokinetic Model for Voriconazole Disposition Predicts Intestinal First-pass Metabolism in Children

Zane, Nicole R., Thakker, Dhiren R.

Journal:

Clinical Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1.10 MB

english, 2014

37

Evidence for the role of OATP and PEPT1 transporters in the intestinal apical transport of amoxicillin

Lee, Christine M., Thakker, Dhiren R.

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2018

Language:

english

File:

PDF, 241 KB

english, 2018

38

[Biotechnology: Pharmaceutical Aspects] Optimizing the “Drug-Like” Properties of Leads in Drug Discovery Volume IV || Case History — Use of ADME Studies for Optimization of Drug Candidates

Borchardt, Ronald T., Kerns, Edward H., Hageman, Michael J., Thakker, Dhiren R., Stevens, James L.

Year:

2006

Language:

english

File:

PDF, 423 KB

english, 2006

39

Changes of mechanisms and product distributions in the hydrolysis of benzo[a]pyrene-7,8-diol 9,10,-epoxide metabolites induced by changes in pH

Whalen, Dale L., Montemarano, Jean A., Thakker, Dhiren R., Yagi, Haruhiko, Jerina, Donald M.

Journal:

Journal of the American Chemical Society

Year:

1977

Language:

english

File:

PDF, 378 KB

english, 1977

40

Structure−Activity Relationship for Enhancement of Paracellular Permeability across Caco-2 Cell Monolayers by 3-Alkylamido-2-alkoxypropylphosphocholines

Ouyang, Hui, Morris-Natschke, Susan L., Ishaq, Khalid S., Ward, Peter, Liu, Dongzhou, Leonard, Sarah, Thakker, Dhiren R.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 99 KB

english, 2002

41

Role of Diaxial Versus Diequatorial Hydroxyl Groups in the Tumorigenic Activity of a Benzo[a]pyrene Bay-Region Diol Epoxide

Richard L. Chang, Alexander W. Wood, Allan H. Conney, Haruhiko Yagi, Jane M. Sayer, Dhiren R. Thakker, Donald M. Jerina and Wayne Levin

Journal:

Proceedings of the National Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 719 KB

english, 1987

42

Molecular and metabolic differences of treatment responders versus nonresponders in a phase 0 clinical trial of metformin in endometrial cancer

Roque, Dario R., Schuler, Kevin M., Rambally, Brooke S., Sampey, Brante, Everett, Ruth, Thakker, Dhiren, Gehrig, Paola A., O’Connor, Siobhan, Makowski, Liza, Bae-Jump, Victoria L.

Journal:

Gynecologic Oncology

Year:

2015

Language:

english

File:

PDF, 51 KB

english, 2015

43

Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

Liang-Shang L. Gan, Dhiren R. Thakker

Journal:

Advanced Drug Delivery Reviews

Year:

1997

Language:

english

File:

PDF, 2.03 MB

english, 1997

44

Enhancing paracellular permeability by modulating epithelial tight junctions

Peter D Ward, Tim K Tippin, Dhiren R Thakker

Journal:

Pharmaceutical Science & Technology Today

Year:

2000

Language:

english

File:

PDF, 313 KB

english, 2000

45

Biorelevant refinement of the Caco-2 cell culture model to assess efficacy of paracellular permeability enhancers

Timothy K. Tippin, Dhiren R. Thakker

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 277 KB

english, 2008

46

Saturable Absorptive Transport of the Hydrophilic Organic Cation Ranitidine in Caco-2 Cells: Role of pH-Dependent Organic Cation Uptake System and P-Glycoprotein

David L. Bourdet, Dhiren R. Thakker

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 592 KB

english, 2006

47

Affinity labeling of catechol O-methyltransferase by N-haloacetyl derivatives of 3,5-dimethoxy-4-hydroxyphenylethylamine and 3,4-dimethoxy-5-hydroxyphenylethylamine. Kinetics of inactivation

Borchardt, Ronald T., Thakker, Dhiren R.

Journal:

Year:

1975

Language:

english

File:

PDF, 1.68 MB

english, 1975

48

Why Does the Intestine Lack Basolateral Efflux Transporters for Cationic Compounds? A Provocative Hypothesis

Proctor, William R., Ming, Xin, Bourdet, David, Han, Tianxiang (Kevin), Everett, Ruth S., Thakker, Dhiren R.

Journal:

Journal of Pharmaceutical Sciences

Year:

2016

Language:

english

File:

PDF, 1.24 MB

english, 2016

49

A novel reaction between acetone and the benzo[c]phenanthrene K-region o-quinone containing a peri-fluoro substituent

Patrick, Mark A., Sethi, Satinder K., Unger, Steve E., Mirsadeghi, Seid, Ribeiro, Anthony A., Thakker, Dhiren R.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 574 KB

english, 1991

50

Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil

Xin Ming, Dhiren R. Thakker

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 385 KB

english, 2010

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